Medicines optimisation focuses on a person-centred approach to the safe and evidence-based use of medicines, with the aim of improving patient outcomes. It has a pivotal role in addressing the treatment burden and potential for harm associated with problematic or inappropriate polypharmacy - when multiple medicines are no longer beneficial, but become problematic or inappropriate when the actual or potential harms of taking medication outweigh the intended benefits, or the intended benefits have not been realised for an individual.